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ea0081oc10.3 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Glucose-dependent insulin secretion is regulated by mitochondrial-associated cannabinoid receptor type 1 (mtCB1)

Allard Camille , Zizzari Philippe , Clark Samantha , Dupuy Nathalie , Bermudez-Silva Francisco-Javier , Delgado Concepcion Lillo , Bellocchio Luigi , Marsicano Giovanni , Quarta Carmelo , Cota Daniela

Type 2 diabetes is among the most prevalent chronic diseases worldwide. Further research is needed to identify new mechanisms that may help preserve the function of insulin-secreting pancreatic β-cells. The cannabinoid receptors type 1 (CB1) and their endogenous ligands, endocannabinoids, exert a key role in regulating of glucose homeostasis, β-cells function, and insulin secretion. Intriguingly, CB1 is not only located at the plasma membrane (pmCB1), but also at the...

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ea0070ep169 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Peripheral cannabinoid–1 receptor blockade potentiates the anti–obesity and anti–diabetic effects of GLP–1 mimetics

Zizzari Philippe , He Rongjun , Bellocchio Luigi , Allard Camille , Clark Samantha , Thierry Leste–lasserre , Marsicano Giovanni , Perez–Tilve Diego , Finan Brian , Cota Daniela , Quarta Carmelo

Obesity and type–2 diabetes (T2D) represent a global health crisis. However, only a few, and often sub–effective pharmacological tools are available to treat these disorders. Though beneficial for glycemic control, GLP–1 receptor (GLP–1R) agonists show scarce weight–lowering and insulin–sensitizing efficacy.New molecules able to selectively block the activity of the cannabinoid receptor type–1 (CB1R) in periphera...

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Endocrine Abstracts

Glucose-dependent insulin secretion is regulated by mitochondrial-associated cannabinoid receptor type 1 (mtCB1)

Peripheral cannabinoid–1 receptor blockade potentiates the anti–obesity and anti–diabetic effects of GLP–1 mimetics

BiosciAbstracts